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Concept
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Insulin-Secreting Cells
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Academic Article
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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
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Academic Article
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
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Academic Article
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
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Academic Article
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
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Academic Article
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
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Academic Article
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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
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Academic Article
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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
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Academic Article
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Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
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Academic Article
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
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Academic Article
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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
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Academic Article
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
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Academic Article
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Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
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Academic Article
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
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Academic Article
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Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
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Academic Article
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
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Academic Article
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10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?
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Academic Article
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Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
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Academic Article
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Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
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Academic Article
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
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Academic Article
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
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Academic Article
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Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?
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Academic Article
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Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
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Academic Article
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
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Academic Article
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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
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Academic Article
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
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Academic Article
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
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Academic Article
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The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
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Academic Article
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
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Academic Article
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Academic Article
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
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Academic Article
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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
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Academic Article
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
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Academic Article
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Formation of a human ß-cell population within pancreatic islets is set early in life.
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Academic Article
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Degradation of islet amyloid polypeptide by neprilysin.
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Academic Article
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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
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Academic Article
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How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
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Academic Article
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
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Academic Article
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PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
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Academic Article
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
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Academic Article
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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
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Academic Article
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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
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Academic Article
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
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Academic Article
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
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Academic Article
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
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Academic Article
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Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
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Academic Article
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IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
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Academic Article
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
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Academic Article
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ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
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Academic Article
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Islet autoantigens: structure, function, localization, and regulation.
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Academic Article
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Direct autocrine action of insulin on ß-cells: does it make physiological sense?
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
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Academic Article
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Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
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Academic Article
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Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
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Academic Article
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SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
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Academic Article
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Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
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Academic Article
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
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Academic Article
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ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats.
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Academic Article
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The dynamic plasticity of insulin production in ß-cells.
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Academic Article
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Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
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Academic Article
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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Academic Article
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A fluorescent timer reporter enables sorting of insulin secretory granules by age.
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Academic Article
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Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
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Academic Article
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Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
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Grant
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Mitogenic Signal Transduction in Pancreatic Beta-Cells
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Grant
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Metabolic Control of Insulin Exocytosis
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Grant
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Central Control of Pancreatic Islet Function
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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